Recent studies have revealed a new aspect of physiological regulation in which microRNAs (miRNAs) play fundamental roles in diverse biological and pathological processes.Furthermore, it was recently discovered that miRNAs are stably secreted into blood and that circulating miRNAs may play important roles in cell-cell communication.Here, we examined

The emergence of the Flywheel Axle SARS-CoV-2 coronavirus pandemic in China in late 2019 led to the fast development of efficient therapeutics.Of the major structural proteins encoded by the SARS-CoV-2 genome, the SPIKE (S) protein has attracted considerable research interest because of the central role it plays in virus entry into host cells.There

Background: The most critically ill patients with coronavirus disease 2019 (COVID-19) may require advanced support modalities, such as veno-venous extracorporeal membrane oxygenation (VV-ECMO).A systematic, methodical approach to a respiratory pandemic on a state and institutional level is critical.Methods: We conducted retrospective review of our

Ruminants are foregut fermenters that have the remarkable ability of converting plant polymers that are indigestible to humans into assimilable comestibles like meat and milk, which are cornerstones of human nutrition.Ruminants establish a symbiotic relationship with their microbiome, and the latter is the workhorse of carbohydrate fermentation.On

BackgroundLiquid biopsies enable the detection of circulating tumor DNA (ctDNA).However, the clinical significance of KRAS-mutated ctDNA for pancreatic cancer has been inconsistent with respect to its prognostic and predictive potential.Methods and findingsA total of 422 blood samples were collected from 78 patients undergoing treatments for locali